Formation of regulatory patterns during signal propagation in a Mammalian cellular network.
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ABSTRACT:
SUBMITTER: Ma'ayan A
PROVIDER: S-EPMC3032439 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
Formation of regulatory patterns during signal propagation in a Mammalian cellular network.
Ma'ayan Avi A Jenkins Sherry L SL Neves Susana S Hasseldine Anthony A Grace Elizabeth E Dubin-Thaler Benjamin B Eungdamrong Narat J NJ Weng Gehzi G Ram Prahlad T PT Rice J Jeremy JJ Kershenbaum Aaron A Stolovitzky Gustavo A GA Blitzer Robert D RD Iyengar Ravi R
Science (New York, N.Y.) 20050801 5737
We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity ...[more]
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