Ontology highlight
ABSTRACT:
SUBMITTER: Baish JW
PROVIDER: S-EPMC3033252 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Baish James W JW Stylianopoulos Triantafyllos T Lanning Ryan M RM Kamoun Walid S WS Fukumura Dai D Munn Lance L LL Jain Rakesh K RK
Proceedings of the National Academy of Sciences of the United States of America 20110111 5
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascular geometry--δ(max) and λ--readily obtained from vascular images, capture these differences and link vascular structure to delivery in both tissue types. The longest time needed to bring materials to their destination scales with the square of δ(max), ...[more]