Ontology highlight
ABSTRACT:
SUBMITTER: Boitano AE
PROVIDER: S-EPMC3033342 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100805 5997
Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSCs identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Mechanistic studie ...[more]