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A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression.

ABSTRACT: Obesity is associated with clinical depression among women. However, depressed women are often excluded from weight loss trials.This study examined treatment outcomes among women with comorbid obesity and depression.Two hundred three (203) women were randomized to behavioral weight loss (n?=?102) or behavioral weight loss combined with cognitive-behavioral depression management (n?=?101).Average participant age was 52 years; mean baseline body mass index was 39 kg/m(2). Mean Patient Health Questionnaire and Hopkins Symptom Checklist (SCL-20) scores indicated moderate to severe baseline depression. Weight loss and SCL-20 changes did not differ between groups at 6 or 12 months in intent-to-treat analyses (p?=?0.26 and 0.55 for weight, p?=?0.70 and 0.25 for depressive symptoms).Depressed obese women lost weight and demonstrated improved mood in both treatment programs. Future weight loss trials are encouraged to enroll depressed women.

SUBMITTER: Linde JA

PROVIDER: S-EPMC3033656 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression.

Linde Jennifer A JA Simon Gregory E GE Ludman Evette J EJ Ichikawa Laura E LE Operskalski Belinda H BH Arterburn David D Rohde Paul P Finch Emily A EA Jeffery Robert W RW

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 20110201 1

<h4>Background</h4>Obesity is associated with clinical depression among women. However, depressed women are often excluded from weight loss trials.<h4>Purpose</h4>This study examined treatment outcomes among women with comorbid obesity and depression.<h4>Methods</h4>Two hundred three (203) women were randomized to behavioral weight loss (n = 102) or behavioral weight loss combined with cognitive-behavioral depression management (n = 101).<h4>Results</h4>Average participant age was 52 years; mean ...[more]

PMID: 20878292

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Project description:BACKGROUND:Antipsychotic-treated youth have increased risk for the development of obesity and type 2 diabetes. Behavioral weight loss treatments show promise in reducing obesity and diabetes risk in antipsychotic treated adults, but have received no study in antipsychotic treated youth. OBJECTIVE:We describe a rationale for behavioral weight loss interventions in high-weight antipsychotic treated youth, and report behavioral, anthropomorphic, and metabolic findings from a case series of obese antipsychotic-treated adolescents participating in a short-term, family-based behavioral weight loss intervention. METHODS:We adapted the Traffic Light Plan, a 16-week family-based weight loss intervention that promotes healthy energy balance using the colors of the traffic light to categorize the nutritional value of foods and intensity of physical activity, adapting a social ecological framework to address health behavior change in multiple social contexts. The intervention was administered to three obese adolescents with long-term antipsychotic medication exposure. Efficacy of the intervention was evaluated with a battery of anthropomorphic and metabolic assessments including weight, body mass index percentile, whole body adiposity, liver fat content, and fasting plasma glucose and lipids. Participants and their parents also filled out a treatment satisfaction questionnaire upon study completion. RESULTS:Two males and 1 female (all aged 14 years) participated. All 3 participants attended all 16 sessions, and experienced beneficial changes in adiposity, fasting lipids and liver fat content associated with weight stabilization or weight loss. Adolescents and their parents all reported a high level of satisfaction with the treatment. CONCLUSIONS:Family-based behavioral weight loss treatment can be feasibly delivered and is acceptable to antipsychotic-treated youth and their families. Randomized controlled trials are needed to fully evaluate the effectiveness and acceptability of behavioral weight loss interventions in antipsychotic treated youth and their families.

Dataset Information

A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression.

Publications

A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression.

Similar Datasets

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