Ontology highlight
ABSTRACT:
SUBMITTER: Palii CG
PROVIDER: S-EPMC3034015 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Palii Carmen G CG Perez-Iratxeta Carolina C Yao Zizhen Z Cao Yi Y Dai Fengtao F Davison Jerry J Atkins Harold H Allan David D Dilworth F Jeffrey FJ Gentleman Robert R Tapscott Stephen J SJ Brand Marjorie M
The EMBO journal 20101221 3
TAL1/SCL is a master regulator of haematopoiesis whose expression promotes opposite outcomes depending on the cell type: differentiation in the erythroid lineage or oncogenesis in the T-cell lineage. Here, we used a combination of ChIP sequencing and gene expression profiling to compare the function of TAL1 in normal erythroid and leukaemic T cells. Analysis of the genome-wide binding properties of TAL1 in these two haematopoietic lineages revealed new insight into the mechanism by which transcr ...[more]