Ontology highlight
ABSTRACT:
SUBMITTER: de Pooter RF
PROVIDER: S-EPMC6504590 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20190408 10
Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis ...[more]