Ontology highlight
ABSTRACT:
SUBMITTER: Curreli F
PROVIDER: S-EPMC3034313 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Curreli Francesca F Zhang Hongtao H Zhang Xihui X Pyatkin Ilya I Victor Zagorodnikov Z Altieri Andrea A Debnath Asim K AK
Bioorganic & medicinal chemistry 20101125 1
The hydrophobic cavity of the C-terminal domain (CTD) of HIV-1 capsid has been recently validated as potential target for antiviral drugs by peptide-based inhibitors; however, there is no report yet of any small molecule compounds that target this hydrophobic cavity. In order to fill this gap and discover new classes of ant-HIV-1 inhibitors, we undertook a docking-based virtual screening and subsequent analog search, and medicinal chemistry approaches to identify small molecule inhibitors agains ...[more]