Ontology highlight
ABSTRACT:
SUBMITTER: Kim BH
PROVIDER: S-EPMC3034357 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Kim Byung-Hak BH Oh Sei-Ryang SR Yin Chang-Hong CH Lee Sangku S Kim Eun-Ah EA Kim Min-Seok MS Sandoval Claudio C Jayabose Somasundaram S Bach Erika A EA Lee Hyeong-Kyu HK Baeg Gyeong-Hun GH
British journal of haematology 20090929 1
In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput screening was performed using a plant extract library that identified Nb-(alpha-hydroxynaphthoyl)serotonin called MS-1020 as a novel JAK3 inhibitor. MS-1020 potently inhibited persistently-active STAT3 in a cell type-specific manner. Further examination showed that MS-1020 selectively blocked constitutively-active JAK3 and consistently suppressed inter ...[more]