Ontology highlight
ABSTRACT:
SUBMITTER: Ortiz-Meoz RF
PROVIDER: S-EPMC4475500 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Ortiz-Meoz Rodrigo F RF Jiang Jiaoyang J Lazarus Michael B MB Orman Marina M Janetzko John J Fan Chenguang C Duveau Damien Y DY Tan Zhi-Wei ZW Thomas Craig J CJ Walker Suzanne S
ACS chemical biology 20150318 6
O-GlcNAc transferase (OGT) is an essential mammalian enzyme that regulates numerous cellular processes through the attachment of O-linked N-acetylglucosamine (O-GlcNAc) residues to nuclear and cytoplasmic proteins. Its targets include kinases, phosphatases, transcription factors, histones, and many other intracellular proteins. The biology of O-GlcNAc modification is still not well understood, and cell-permeable inhibitors of OGT are needed both as research tools and for validating OGT as a ther ...[more]