Ontology highlight
ABSTRACT:
SUBMITTER: Khodarev NN
PROVIDER: S-EPMC3034477 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Khodarev Nikolai N NN Pitroda Sean P SP Beckett Michael A MA MacDermed Dhara M DM Huang Lei L Kufe Donald W DW Weichselbaum Ralph R RR
Cancer research 20090324 7
The Mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in diverse human malignancies including breast and lung cancer. Although MUC1 modulates the activity of several transcription factors, there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of MUC1-induced genes in predicting outcome for cancer patients. We have developed an experimental model of MUC1-induced transformation that has identified the activation of gene families involv ...[more]