Ontology highlight
ABSTRACT:
SUBMITTER: Huttlin EL
PROVIDER: S-EPMC3035969 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Huttlin Edward L EL Jedrychowski Mark P MP Elias Joshua E JE Goswami Tapasree T Rad Ramin R Beausoleil Sean A SA Villén Judit J Haas Wilhelm W Sowa Mathew E ME Gygi Steven P SP
Cell 20101201 7
Although most tissues in an organism are genetically identical, the biochemistry of each is optimized to fulfill its unique physiological roles, with important consequences for human health and disease. Each tissue's unique physiology requires tightly regulated gene and protein expression coordinated by specialized, phosphorylation-dependent intracellular signaling. To better understand the role of phosphorylation in maintenance of physiological differences among tissues, we performed proteomic ...[more]