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A mouse tissue transcription factor atlas.

ABSTRACT: Transcription factors (TFs) drive various biological processes ranging from embryonic development to carcinogenesis. Here, we employ a recently developed concatenated tandem array of consensus TF response elements (catTFRE) approach to profile the activated TFs in 24 adult and 8 fetal mouse tissues on proteome scale. A total of 941 TFs are quantitatively identified, representing over 60% of the TFs in the mouse genome. Using an integrated omics approach, we present a TF network in the major organs of the mouse, allowing data mining and generating knowledge to elucidate the roles of TFs in various biological processes, including tissue type maintenance and determining the general features of a physiological system. This study provides a landscape of TFs in mouse tissues that can be used to elucidate transcriptional regulatory specificity and programming and as a baseline that may facilitate understanding diseases that are regulated by TFs.

SUBMITTER: Zhou Q

PROVIDER: S-EPMC5413951 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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A mouse tissue transcription factor atlas.

Zhou Quan Q Liu Mingwei M Xia Xia X Gong Tongqing T Feng Jinwen J Liu Wanlin W Liu Yang Y Zhen Bei B Wang Yi Y Ding Chen C Qin Jun J

Nature communications 20170421

Transcription factors (TFs) drive various biological processes ranging from embryonic development to carcinogenesis. Here, we employ a recently developed concatenated tandem array of consensus TF response elements (catTFRE) approach to profile the activated TFs in 24 adult and 8 fetal mouse tissues on proteome scale. A total of 941 TFs are quantitatively identified, representing over 60% of the TFs in the mouse genome. Using an integrated omics approach, we present a TF network in the major orga ...[more]

PMID: 28429721

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