Ontology highlight
ABSTRACT:
SUBMITTER: Ohsaka Y
PROVIDER: S-EPMC3036159 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Ohsaka Yasuhito Y Nishino Hoyoku H
Genetics and molecular biology 20101001 4
Research has been conducted to identify sequence polymorphisms of gene promoter regions in patients and control subjects, including normal individuals, and to determine the influence of these polymorphisms on transcriptional regulation in cells that express wild-type or mutant p53. In this study we isolated genomic DNA from whole blood of healthy Japanese individuals and sequenced the promoter regions of the MDM2, p53, and p16(INK4a) genes. We identified polymorphisms comprising 3 nucleotide sub ...[more]