Ontology highlight
ABSTRACT:
SUBMITTER: Booker M
PROVIDER: S-EPMC3036618 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Booker Matthew M Samsonova Anastasia A AA Kwon Young Y Flockhart Ian I Mohr Stephanie E SE Perrimon Norbert N
BMC genomics 20110120
<h4>Background</h4>High-throughput screening using RNAi is a powerful gene discovery method but is often complicated by false positive and false negative results. Whereas false positive results associated with RNAi reagents has been a matter of extensive study, the issue of false negatives has received less attention.<h4>Results</h4>We performed a meta-analysis of several genome-wide, cell-based Drosophila RNAi screens, together with a more focused RNAi screen, and conclude that the rate of fals ...[more]