Ontology highlight
ABSTRACT:
SUBMITTER: Aubert M
PROVIDER: S-EPMC3036713 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Aubert Martine M Ryu Byoung Y BY Banks Lindsey L Rawlings David J DJ Scharenberg Andrew M AM Jerome Keith R KR
PloS one 20110209 2
Current antiviral therapy does not cure HIV-infected individuals because the virus establishes lifelong latent infection within long-lived memory T cells as integrated HIV proviral DNA. Here, we report a new therapeutic approach that aims to cure cells of latent HIV infection by rendering latent virus incapable of replication and pathogenesis via targeted cellular mutagenesis of essential viral genes. This is achieved by using a homing endonuclease to introduce DNA double-stranded breaks (dsb) w ...[more]