Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari G
PROVIDER: S-EPMC3037354 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Ferrari Guido G Korber Bette B Goonetilleke Nilu N Liu Michael K P MK Turnbull Emma L EL Salazar-Gonzalez Jesus F JF Hawkins Natalie N Self Steve S Watson Sydeaka S Betts Michael R MR Gay Cynthia C McGhee Kara K Pellegrino Pierre P Williams Ian I Tomaras Georgia D GD Haynes Barton F BF Gray Clive M CM Borrow Persephone P Roederer Mario M McMichael Andrew J AJ Weinhold Kent J KJ
PLoS pathogens 20110210 2
In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral therapy-naïve subjects were studied in detail between 1 and 87 weeks following onset of symptoms of acute HIV-1 infection. Synthetic peptides representing the autologous transmitted/founder HIV-1 sequences ...[more]