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Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

ABSTRACT: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

SUBMITTER: Ritchie AJ

PROVIDER: S-EPMC4180588 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

Ritchie Adam John AJ Cai Fangping F Smith Nicola M G NM Chen Sheri S Song Hongshuo H Brackenridge Simon S Abdool Karim Salim S SS Korber Bette T BT McMichael Andrew J AJ Gao Feng F Goonetilleke Nilu N

Retrovirology 20140912

<h4>Background</h4>A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.<h4>Results</h4>Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses th ...[more]

PMID: 25212771

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