Ontology highlight
ABSTRACT:
SUBMITTER: Wipasa J
PROVIDER: S-EPMC3037361 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Wipasa Jiraprapa J Okell Lucy L Sakkhachornphop Supachai S Suphavilai Chaisuree C Chawansuntati Kriangkrai K Liewsaree Witaya W Hafalla Julius C R JC Riley Eleanor M EM
PLoS pathogens 20110210 2
Immunity to malaria is widely believed to wane in the absence of reinfection, but direct evidence for the presence or absence of durable immunological memory to malaria is limited. Here, we analysed malaria-specific CD4+ T cell responses of individuals living in an area of low malaria transmission in northern Thailand, who had had a documented clinical attack of P. falciparum and/or P. vivax in the past 6 years. CD4+ T cell effector memory (CD45RO+) IFN-γ (24 hours ex vivo restimulation) and cul ...[more]