Unknown

Dataset Information

0

Association of IFN-gamma and IL-10 gene variants with the risk of extrapulmonary tuberculosis.


ABSTRACT: Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a chronic infectious disease. Interferon-gamma (IFN-γ) is an important cytokine imparting resistance to mycobacterial diseases. It is believed that IFN-γ and Interleukin-10 (IL-10) play divergent roles in the host immune system against MTB infection. IL-10 is an important inhibitory cytokine and helps balancing the inflammatory and immune responses. IL-10 is involved in down regulation of Th1 cytokines, MHC class II antigen and co-stimulatory molecular expression on macrophages, while IFN-γ results in macrophage activation allowing them to exert the microbicidal role. The objectives were to find out the association of IL-10 (-1082 A/G) and IFN-γ (+874 A/T) single nucleotide polymorphisms (SNPs) with extrapulmonary tuberculosis in ethnic Kashmiri population. A total of 100 extrapulmonary tuberculosis cases and 102 healthy controls were analyzed for IL-10 (-1082 A/G) and IFN- γ (+874 A/T) SNPs using Allele-Specific PCR. We found a significant association of IFN-γ + 874 'TT' genotype with extrapulmonary tuberculosis (p = 0.006) and in case of IL-10 (-1082 A/G) we found a significant association with extrapulmonary tuberculosis under recessive model (GG vs GA + AA) (p = 0.03) in Kashmiri population. IL-10 (-1082 A/G) and IFN-γ (+874 A/T) have a significant association with extrapulmonary tuberculosis in ethnic Kashmiri population.

SUBMITTER: Wani BA 

PROVIDER: S-EPMC8324987 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of IFN-gamma and IL-10 gene variants with the risk of extrapulmonary tuberculosis.

Wani Bilal Ahmad BA   Shehjar Faheem F   Shah Sonaullah S   Koul Ajaz A   Yusuf Adfar A   Murtaza Masqooba M   Singh Rajni R   Althobaiti Fayez F   Aldhahrani Adil A   Afroze Dil D  

Saudi journal of biological sciences 20210617 8


Tuberculosis (TB) caused by <i>Mycobacterium tuberculosis</i> (MTB) is a chronic infectious disease. <i>Interferon-gamma (IFN-γ)</i> is an important cytokine imparting resistance to mycobacterial diseases. It is believed that <i>IFN-γ</i> and <i>Interleukin-10 (IL-10)</i> play divergent roles in the host immune system against <i>MTB</i> infection. <i>IL-10</i> is an important inhibitory cytokine and helps balancing the inflammatory and immune responses. <i>IL-10</i> is involved in down regulatio  ...[more]

Similar Datasets

| S-EPMC5845669 | biostudies-literature
| S-EPMC4111910 | biostudies-literature
| S-EPMC2679252 | biostudies-literature
| S-EPMC8917052 | biostudies-literature
| S-EPMC11384583 | biostudies-literature
| S-EPMC7605464 | biostudies-literature
| S-EPMC4170673 | biostudies-literature
| S-EPMC4817970 | biostudies-literature
| S-EPMC4718545 | biostudies-literature
| S-EPMC7124215 | biostudies-literature