Ontology highlight
ABSTRACT:
SUBMITTER: Gesteira TF
PROVIDER: S-EPMC3037646 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Gesteira Tarsis F TF Coulson-Thomas Vivien J VJ Taunay-Rodrigues Alessandro A Oliveira Vitor V Thacker Bryan E BE Juliano Maria A MA Pasqualini Renata R Arap Wadih W Tersariol Ivarne L S IL Nader Helena B HB Esko Jeffrey D JD Pinhal Maria A S MA
The Journal of biological chemistry 20100202 7
N-Deacetylase-N-sulfotransferase 1 (Ndst1) catalyzes the initial modification of heparan sulfate and heparin during their biosynthesis by removal of acetyl groups from subsets of N-acetylglucosamine units and subsequent sulfation of the resulting free amino groups. In this study, we used a phage display library to select peptides that interact with Ndst1, with the aim of finding inhibitors of the enzyme. The phage library consisted of cyclic random 10-mer peptides expressed in the phage capsid p ...[more]