Ontology highlight
ABSTRACT:
SUBMITTER: Sheng J
PROVIDER: S-EPMC3103355 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Sheng Juzheng J Liu Renpeng R Xu Yongmei Y Liu Jian J
The Journal of biological chemistry 20110328 22
Heparan sulfate (HS) is a highly sulfated polysaccharide participated in essential physiological functions from regulating cell growth to blood coagulation. HS contains sulfated domains known as N-S domains and low sulfate domains known as N-Ac domains. The distribution of the domain structures is likely governed by the action of glucosaminyl N-deacetylase/N-sulfotransferase (NDST). Here, we sought to determine the substrate specificity of NDST using model substrates and recombinant NDST protein ...[more]