Ontology highlight
ABSTRACT:
SUBMITTER: Slattery ML
PROVIDER: S-EPMC3038588 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Slattery Martha L ML Lundgreen Abbie A Herrick Jennifer S JS Wolff Roger K RK
Mutation research 20101028 1-2
RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the carcinogenic process, including regulation of cell growth, insulin, and inflammation. We evaluated genetic variation in their candidate genes to obtain a better understanding of their association with colon and rectal cancer. We used data from two population-based case-control studies of colon (n=1574 cases, 1940 controls) and rectal (n=791 cases, 999 controls) cancer. We observed genetic variation in RP ...[more]