Ontology highlight
ABSTRACT:
SUBMITTER: Slattery ML
PROVIDER: S-EPMC3155002 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Slattery Martha L ML Lundgreen Abbie A Herrick Jennifer S JS Kadlubar Susan S Caan Bette J BJ Potter John D JD Wolff Roger K RK
International journal of cancer 20110427 3
Bone morphogenetic proteins (BMP) are part of the TGF-β-signaling pathway; genetic variation in these genes may be involved in colorectal cancer. In this study, we evaluated the association between genetic variation in BMP1 (11 tagSNPs), BMP2 (5 tagSNPs), BMP4 (3 tagSNPs), BMPR1A (9 tagSNPs), BMPR1B (21 tagSNPs), BMPR2 (11 tagSNPs) and GDF10 (7 tagSNPs) with risk of colon and rectal cancer and tumor molecular phenotype. We used data from population-based case-control studies (colon cancer n = 1, ...[more]