Ontology highlight
ABSTRACT:
SUBMITTER: Novotny I
PROVIDER: S-EPMC3038649 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20101222 4
The U4/U6·U5 tri-small nuclear ribonucleoprotein particle (tri-snRNP) is an essential pre-mRNA splicing factor, which is assembled in a stepwise manner before each round of splicing. It was previously shown that the tri-snRNP is formed in Cajal bodies (CBs), but little is known about the dynamics of this process. Here we created a mathematical model of tri-snRNP assembly in CBs and used it to fit kinetics of individual snRNPs monitored by fluorescence recovery after photobleaching. A global fitt ...[more]