Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.
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ABSTRACT:
SUBMITTER: Tandon P
PROVIDER: S-EPMC3038712 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.
Tandon Preeti P Gallo Catherine A CA Khatri Shikha S Barger Jennifer F JF Yepiskoposyan Hasmik H Plas David R DR
Proceedings of the National Academy of Sciences of the United States of America 20110124 6
Pten inactivation promotes cell survival in leukemia cells by activating glycolytic metabolism. We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient cells suppressed glycolysis and induced apoptosis. S6K1 knockdown decreased expression of HIF-1α, and HIF-1α was sufficient to restore glycolysis and survival of cells lacking S6K1. In the Pten(fl/fl) Mx1-Cre(+) mouse model of leukemia, S6K1 deletion delayed the development of leukemia. Thus, S6K1 is a critical mediator of ...[more]
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