Ontology highlight
ABSTRACT:
SUBMITTER: Barrette I
PROVIDER: S-EPMC30388 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Barrette I I Poisson G G Gendron P P Major F F
Nucleic acids research 20010201 3
The human prion gene contains five copies of a 24 nt repeat that is highly conserved among species. An analysis of folding free energies of the human prion mRNA, in particular in the repeat region, suggested biased codon selection and the presence of RNA patterns. In particular, pseudoknots, similar to the one predicted by Wills in the human prion mRNA, were identified in the repeat region of all available prion mRNAs available in GenBank, but not those of birds and the red slider turtle. An ali ...[more]