Multiple loci associated with indices of renal function and chronic kidney disease.
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ABSTRACT:
SUBMITTER: Kottgen A
PROVIDER: S-EPMC3039280 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Multiple loci associated with indices of renal function and chronic kidney disease.
Köttgen Anna A Glazer Nicole L NL Dehghan Abbas A Hwang Shih-Jen SJ Katz Ronit R Li Man M Yang Qiong Q Gudnason Vilmundur V Launer Lenore J LJ Harris Tamara B TB Smith Albert V AV Arking Dan E DE Astor Brad C BC Boerwinkle Eric E Ehret Georg B GB Ruczinski Ingo I Scharpf Robert B RB Chen Yii-Der Ida YD de Boer Ian H IH Haritunians Talin T Lumley Thomas T Sarnak Mark M Siscovick David D Benjamin Emelia J EJ Levy Daniel D Upadhyay Ashish A Aulchenko Yurii S YS Hofman Albert A Rivadeneira Fernando F Uitterlinden André G AG van Duijn Cornelia M CM Chasman Daniel I DI Paré Guillaume G Ridker Paul M PM Kao W H Linda WH Witteman Jacqueline C JC Coresh Josef J Shlipak Michael G MG Fox Caroline S CS
Nature genetics 20090510 6
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1.73 m(2)) in European-ancestry participants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and test ...[more]
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