Genetic loci influencing kidney function and chronic kidney disease.
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ABSTRACT:
SUBMITTER: Chambers JC
PROVIDER: S-EPMC3748585 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Genetic loci influencing kidney function and chronic kidney disease.
Chambers John C JC Zhang Weihua W Lord Graham M GM van der Harst Pim P Lawlor Debbie A DA Sehmi Joban S JS Gale Daniel P DP Wass Mark N MN Ahmadi Kourosh R KR Bakker Stephan J L SJ Beckmann Jacqui J Bilo Henk J G HJ Bochud Murielle M Brown Morris J MJ Caulfield Mark J MJ Connell John M C JM Cook H Terence HT Cotlarciuc Ioana I Davey Smith George G de Silva Ranil R Deng Guohong G Devuyst Olivier O Dikkeschei Lambert D LD Dimkovic Nada N Dockrell Mark M Dominiczak Anna A Ebrahim Shah S Eggermann Thomas T Farrall Martin M Ferrucci Luigi L Floege Jurgen J Forouhi Nita G NG Gansevoort Ron T RT Han Xijin X Hedblad Bo B Homan van der Heide Jaap J JJ Hepkema Bouke G BG Hernandez-Fuentes Maria M Hypponen Elina E Johnson Toby T de Jong Paul E PE Kleefstra Nanne N Lagou Vasiliki V Lapsley Marta M Li Yun Y Loos Ruth J F RJ Luan Jian'an J Luttropp Karin K Maréchal Céline C Melander Olle O Munroe Patricia B PB Nordfors Louise L Parsa Afshin A Peltonen Leena L Penninx Brenda W BW Perucha Esperanza E Pouta Anneli A Prokopenko Inga I Roderick Paul J PJ Ruokonen Aimo A Samani Nilesh J NJ Sanna Serena S Schalling Martin M Schlessinger David D Schlieper Georg G Seelen Marc A J MA Shuldiner Alan R AR Sjögren Marketa M Smit Johannes H JH Snieder Harold H Soranzo Nicole N Spector Timothy D TD Stenvinkel Peter P Sternberg Michael J E MJ Swaminathan Ramasamyiyer R Tanaka Toshiko T Ubink-Veltmaat Lielith J LJ Uda Manuela M Vollenweider Peter P Wallace Chris C Waterworth Dawn D Zerres Klaus K Waeber Gerard G Wareham Nicholas J NJ Maxwell Patrick H PH McCarthy Mark I MI Jarvelin Marjo-Riitta MR Mooser Vincent V Abecasis Goncalo R GR Lightstone Liz L Scott James J Navis Gerjan G Elliott Paul P Kooner Jaspal S JS
Nature genetics 20100411 5
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. ...[more]
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