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Genetic loci influencing kidney function and chronic kidney disease.

ABSTRACT: Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

SUBMITTER: Chambers JC 

PROVIDER: S-EPMC3748585 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Genetic loci influencing kidney function and chronic kidney disease.

Chambers John C JC   Zhang Weihua W   Lord Graham M GM   van der Harst Pim P   Lawlor Debbie A DA   Sehmi Joban S JS   Gale Daniel P DP   Wass Mark N MN   Ahmadi Kourosh R KR   Bakker Stephan J L SJ   Beckmann Jacqui J   Bilo Henk J G HJ   Bochud Murielle M   Brown Morris J MJ   Caulfield Mark J MJ   Connell John M C JM   Cook H Terence HT   Cotlarciuc Ioana I   Davey Smith George G   de Silva Ranil R   Deng Guohong G   Devuyst Olivier O   Dikkeschei Lambert D LD   Dimkovic Nada N   Dockrell Mark M   Dominiczak Anna A   Ebrahim Shah S   Eggermann Thomas T   Farrall Martin M   Ferrucci Luigi L   Floege Jurgen J   Forouhi Nita G NG   Gansevoort Ron T RT   Han Xijin X   Hedblad Bo B   Homan van der Heide Jaap J JJ   Hepkema Bouke G BG   Hernandez-Fuentes Maria M   Hypponen Elina E   Johnson Toby T   de Jong Paul E PE   Kleefstra Nanne N   Lagou Vasiliki V   Lapsley Marta M   Li Yun Y   Loos Ruth J F RJ   Luan Jian'an J   Luttropp Karin K   Maréchal Céline C   Melander Olle O   Munroe Patricia B PB   Nordfors Louise L   Parsa Afshin A   Peltonen Leena L   Penninx Brenda W BW   Perucha Esperanza E   Pouta Anneli A   Prokopenko Inga I   Roderick Paul J PJ   Ruokonen Aimo A   Samani Nilesh J NJ   Sanna Serena S   Schalling Martin M   Schlessinger David D   Schlieper Georg G   Seelen Marc A J MA   Shuldiner Alan R AR   Sjögren Marketa M   Smit Johannes H JH   Snieder Harold H   Soranzo Nicole N   Spector Timothy D TD   Stenvinkel Peter P   Sternberg Michael J E MJ   Swaminathan Ramasamyiyer R   Tanaka Toshiko T   Ubink-Veltmaat Lielith J LJ   Uda Manuela M   Vollenweider Peter P   Wallace Chris C   Waterworth Dawn D   Zerres Klaus K   Waeber Gerard G   Wareham Nicholas J NJ   Maxwell Patrick H PH   McCarthy Mark I MI   Jarvelin Marjo-Riitta MR   Mooser Vincent V   Abecasis Goncalo R GR   Lightstone Liz L   Scott James J   Navis Gerjan G   Elliott Paul P   Kooner Jaspal S JS  

Nature genetics 20100411 5

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. ...[more]

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