Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar P
PROVIDER: S-EPMC3039521 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Sarkar Paramita P Saleh Tamjeed T Tzeng Shiou-Ru SR Birge Raymond B RB Kalodimos Charalampos G CG
Nature chemical biology 20101205 1
Proline switches, controlled by cis-trans isomerization, have emerged as a particularly effective regulatory mechanism in a wide range of biological processes. Here we report the structures of both the cis and trans conformers of a proline switch in the Crk signaling protein. Proline isomerization toggles Crk between two conformations: an autoinhibitory conformation, stabilized by the intramolecular association of two tandem SH3 domains in the cis form, and an uninhibited, activated conformation ...[more]