Ontology highlight
ABSTRACT:
SUBMITTER: Meharena HS
PROVIDER: S-EPMC3797032 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Meharena Hiruy S HS Chang Philip P Keshwani Malik M MM Oruganty Krishnadev K Nene Aishwarya K AK Kannan Natarajan N Taylor Susan S SS Kornev Alexandr P AP
PLoS biology 20131015 10
Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain. Our previous computational studies proposed a model stating that a properly assembled nonlinear motif termed the Regulatory (R) spine is essential for catalytic activity of EPKs. Here we define the required intramolecular interactions and biochemical properties of the R-spine and the newly identified "Shell" that surrounds the R-spine using ...[more]