Ontology highlight
ABSTRACT:
SUBMITTER: Lee YE
PROVIDER: S-EPMC3039703 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Analytical chemistry 20101001 20
The development of sensors for noninvasive determination of oxygen levels in live cells and tissues is critical for the understanding of cellular functions, as well as for monitoring the status of disease, such as cancer, and for predicting the efficacy of therapy. We describe such nontoxic, targeted, and ratiometric 30 nm oxygen nanosensors made of polyacrylamide hydrogel, near-infrared (NIR) luminescent dyes, and surface-conjugated tumor-specific peptides. They enabled noninvasive real-time mo ...[more]