Ontology highlight
ABSTRACT:
SUBMITTER: Weaver DJ
PROVIDER: S-EPMC3040298 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
European journal of immunology 20100301 3
C5a is a proinflammatory mediator that has recently been shown to regulate adaptive immune responses. Here we demonstrate that C5a receptor (C5aR) signaling in DC affects the development of Treg and Th17 cells. Genetic ablation or pharmacological targeting of the C5aR in spleen-derived DC results in increased production of TGF-beta leading to de novo differentiation of Foxp3(+) Treg within 12 h after co-incubation with CD4(+) T cells from DO11.10/RAG2(-/-) mice. Stimulation of C5aR(-/-) DC with ...[more]