Ontology highlight
ABSTRACT:
SUBMITTER: Rubin BP
PROVIDER: S-EPMC3040414 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Rubin Brian P BP Nishijo Koichi K Chen Hung-I Harry HI Yi Xiaolan X Schuetze David P DP Pal Ranadip R Prajapati Suresh I SI Abraham Jinu J Arenkiel Benjamin R BR Chen Qing-Rong QR Davis Sean S McCleish Amanda T AT Capecchi Mario R MR Michalek Joel E JE Zarzabal Lee Ann LA Khan Javed J Yu Zhongxin Z Parham David M DM Barr Frederic G FG Meltzer Paul S PS Chen Yidong Y Keller Charles C
Cancer cell 20110201 2
Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS. Conversely, p53 loss in maturing myoblasts gives rise to eRMS, which have the highest myodifferentiati ...[more]