Characterization of the proteome, diseases and evolution of the human postsynaptic density.
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ABSTRACT:
SUBMITTER: Bayes A
PROVIDER: S-EPMC3040565 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Characterization of the proteome, diseases and evolution of the human postsynaptic density.
Bayés Alex A van de Lagemaat Louie N LN Collins Mark O MO Croning Mike D R MD Whittle Ian R IR Choudhary Jyoti S JS Grant Seth G N SG
Nature neuroscience 20101219 1
We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior. ...[more]
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