Ontology highlight
ABSTRACT:
SUBMITTER: Tumurbaatar I
PROVIDER: S-EPMC3040744 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Tumurbaatar Indra I Cizmecioglu Onur O Hoffmann Ingrid I Grummt Ingrid I Voit Renate R
PloS one 20110217 2
Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations. Whether hCdc14B, the human homolog of yeast Cdc14, plays a similar function in mitosis is not yet known. Here we show that hCdc14B serves a critical role in regulating progression through mitosis, which is distinct from hCdc14A. Unscheduled overexpression of hCdc14B ...[more]