Ontology highlight
ABSTRACT:
SUBMITTER: Hiraoka D
PROVIDER: S-EPMC6829662 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hiraoka Daisaku D Hosoda Enako E Chiba Kazuyoshi K Kishimoto Takeo T
The Journal of cell biology 20190919 11
The kinase cyclin B-Cdk1 complex is a master regulator of M-phase in both mitosis and meiosis. At the G2/M transition, cyclin B-Cdk1 activation is initiated by a trigger that reverses the balance of activities between Cdc25 and Wee1/Myt1 and is further accelerated by autoregulatory loops. In somatic cell mitosis, this trigger was recently proposed to be the cyclin A-Cdk1/Plk1 axis. However, in the oocyte meiotic G2/M transition, in which hormonal stimuli induce cyclin B-Cdk1 activation, cyclin A ...[more]