A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch.
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ABSTRACT:
SUBMITTER: Purcell O
PROVIDER: S-EPMC3040778 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch.
Purcell Oliver O di Bernardo Mario M Grierson Claire S CS Savery Nigel J NJ
PloS one 20110217 2
We present the design and analysis of a synthetic gene network that performs frequency multiplication. It takes oscillatory transcription factor concentrations, such as those produced from the currently available genetic oscillators, as an input, and produces oscillations with half the input frequency as an output. Analysis of the bifurcation structure also reveals novel, programmable multi-functionality; in addition to functioning as a frequency multiplier, the network is able to function as a ...[more]
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