Classifying glycerol dehydratase by its functional residues and purifying selection in its evolution.
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ABSTRACT:
SUBMITTER: Escobar AJ
PROVIDER: S-EPMC3041002 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
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Classifying glycerol dehydratase by its functional residues and purifying selection in its evolution.
Escobar Andres Julian Gutierrez AJ Castaño Dolly Montoya DM
Bioinformation 20101006 4
Glycerol dehydratase (GD) catalyses glycerol reductive conversion to 3-hydroxypropanaldehyde (3-HPA), this being the first step required for the microbial conversion of glycerol to 1, 3 -propanodiol. GD has been functionally characterised to date and two main groups have been determined, one of them being vitamin B(12)-dependent and the other B(12)-independent. GD evolutionary history has been described and an exhaustive analysis made for detecting the functional residues responsible for type I ...[more]
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