Interactions of cytochrome P450s with their ligands.
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ABSTRACT:
SUBMITTER: Conner KP
PROVIDER: S-EPMC3041843 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
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Interactions of cytochrome P450s with their ligands.
Conner Kip P KP Woods Caleb M CM Atkins William M WM
Archives of biochemistry and biophysics 20101019 1
Cytochrome P450s (CYPs) are heme-containing monooxygenases that contribute to an enormous range of enzymatic function including biosynthetic and detoxification roles. This review summarizes recent studies concerning interactions of CYPs with ligands including substrates, inhibitors, and diatomic heme-ligating molecules. These studies highlight the complexity in the relationship between the heme spin state and active site occupancy, the roles of water in directing protein-ligand and ligand-heme i ...[more]
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