Structural diversity of eukaryotic membrane cytochrome p450s.
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ABSTRACT:
SUBMITTER: Johnson EF
PROVIDER: S-EPMC3682514 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Structural diversity of eukaryotic membrane cytochrome p450s.
Johnson Eric F EF Stout C David CD
The Journal of biological chemistry 20130430 24
X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance. ...[more]
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