New functions of aminoacyl-tRNA synthetases beyond translation.
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ABSTRACT:
SUBMITTER: Guo M
PROVIDER: S-EPMC3042954 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
New functions of aminoacyl-tRNA synthetases beyond translation.
Guo Min M Yang Xiang-Lei XL Schimmel Paul P
Nature reviews. Molecular cell biology 20100811 9
Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation. ...[more]
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