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An atom-economic synthesis of nitrogen heterocycles from alkynes.

ABSTRACT: A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones.

SUBMITTER: Trost BM

PROVIDER: S-EPMC3043142 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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An atom-economic synthesis of nitrogen heterocycles from alkynes.

Trost Barry M BM Lumb Jean-Philip JP Azzarelli Joseph M JM

Journal of the American Chemical Society 20110201 4

A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones. ...[more]

PMID: 21175138

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