Ontology highlight
ABSTRACT:
SUBMITTER: Maul-Pavicic A
PROVIDER: S-EPMC3044412 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Maul-Pavicic Andrea A Chiang Samuel C C SC Rensing-Ehl Anne A Jessen Birthe B Fauriat Cyril C Wood Stephanie M SM Sjöqvist Sebastian S Hufnagel Markus M Schulze Ilka I Bass Thilo T Schamel Wolfgang W WW Fuchs Sebastian S Pircher Hanspeter H McCarl Christie-Ann CA Mikoshiba Katsuhiko K Schwarz Klaus K Feske Stefan S Bryceson Yenan T YT Ehl Stephan S
Proceedings of the National Academy of Sciences of the United States of America 20110207 8
Lymphocytes mediate cytotoxicity by polarized release of the contents of cytotoxic granules toward their target cells. Here, we have studied the role of the calcium release-activated calcium channel ORAI1 in human lymphocyte cytotoxicity. Natural killer (NK) cells obtained from an ORAI1-deficient patient displayed defective store-operated Ca(2+) entry (SOCE) and severely defective cytotoxic granule exocytosis leading to impaired target cell lysis. Similar findings were obtained using NK cells fr ...[more]