Ontology highlight
ABSTRACT:
SUBMITTER: Moon H
PROVIDER: S-EPMC7603501 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Moon Hyunji H Min Chanhyuk C Kim Gayoung G Kim Deokhwan D Kim Kwanhyeong K Lee Sang-Ah SA Moon Byeongjin B Yang Susumin S Lee Juyeon J Yang Seung-Joo SJ Cho Steve K SK Lee Gwangrog G Lee Chang Sup CS Park Chul-Seung CS Park Daeho D
Nature communications 20201030 1
Calcium flux regulating intracellular calcium levels is essential and modulated for efficient efferocytosis. However, the molecular mechanism by which calcium flux is modulated during efferocytosis remains elusive. Here, we report that Orai1, a Crbn substrate, is upregulated via its attenuated interaction with Crbn during efferocytosis, which increases calcium influx into phagocytes and thereby promotes efferocytosis. We found that Crbn deficiency promoted phagocytosis of apoptotic cells, which ...[more]