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Production of lantipeptides in Escherichia coli.


ABSTRACT: Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.

SUBMITTER: Shi Y 

PROVIDER: S-EPMC3044485 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Production of lantipeptides in Escherichia coli.

Shi Yanxiang Y   Yang Xiao X   Garg Neha N   van der Donk Wilfred A WA  

Journal of the American Chemical Society 20101129 8


Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids. ...[more]

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