Genetics of Alzheimer disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Bekris LM
PROVIDER: S-EPMC3044597 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Genetics of Alzheimer disease.
Bekris Lynn M LM Yu Chang-En CE Bird Thomas D TD Tsuang Debby W DW
Journal of geriatric psychiatry and neurology 20101201 4
Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have bee ...[more]
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