Ontology highlight
ABSTRACT:
SUBMITTER: Lake CM
PROVIDER: S-EPMC3044681 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
PLoS genetics 20110224 2
Homologous recombination in meiosis is initiated by the programmed induction of double strand breaks (DSBs). Although the Drosophila Spo11 ortholog Mei-W68 is required for the induction of DSBs during meiotic prophase, only one other protein (Mei-P22) has been shown to be required for Mei-W68 to exert this function. We show here that the chromatin-associated protein Trade Embargo (Trem), a C2H2 zinc finger protein, is required to localize Mei-P22 to discrete foci on meiotic chromosomes, and thus ...[more]