Ontology highlight
ABSTRACT:
SUBMITTER: Lake CM
PROVIDER: S-EPMC4703084 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Lake Cathleen M CM Nielsen Rachel J RJ Guo Fengli F Unruh Jay R JR Slaughter Brian D BD Hawley R Scott RS
eLife 20151009
Meiotic recombination begins with the induction of programmed double-strand breaks (DSBs). In most organisms only a fraction of DSBs become crossovers. Here we report a novel meiotic gene, vilya, which encodes a protein with homology to Zip3-like proteins shown to determine DSB fate in other organisms. Vilya is required for meiotic DSB formation, perhaps as a consequence of its interaction with the DSB accessory protein Mei-P22, and localizes to those DSB sites that will mature into crossovers. ...[more]