Ontology highlight
ABSTRACT:
SUBMITTER: Roux J
PROVIDER: S-EPMC3044850 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Roux Julien J Robinson-Rechavi Marc M
Genome research 20101220 3
We analyze here the relation between alternative splicing and gene duplication in light of recent genomic data, with a focus on the human genome. We show that the previously reported negative correlation between level of alternative splicing and family size no longer holds true. We clarify this pattern and show that it is sufficiently explained by two factors. First, genes progressively gain new splice variants with time. The gain is consistent with a selectively relaxed regime, until purifying ...[more]