Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity.
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ABSTRACT:
SUBMITTER: Pendyala G
PROVIDER: S-EPMC3045074 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity.
Pendyala Gurudutt G Trauger Sunia A SA Siuzdak Gary G Fox Howard S HS
AIDS research and human retroviruses 20101007 2
The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression ...[more]
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